39 research outputs found

    GPS Carrier Tracking Loop Performance in the presence of Ionospheric Scintillations

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    The performance of several GPS carrier tracking loops is evaluated using wideband GPS data recorded during strong ionospheric scintillations. The aim of this study is to determine the loop structures and parameters that enable good phase tracking during the power fades and phase dynamics induced by scintillations. Constant-bandwidth and variable-bandwidth loops are studied using theoretical models, simulation, and tests with actual GPS signals. Constant-bandwidth loops with loop bandwidths near 15 Hz are shown to lose phase lock during scintillations. Use of the decision-directed discriminator reduces the carrier lock threshold by ∼1 dB relative to the arctangent and conventional Costas discriminators. A proposed variablebandwidth loop based on a Kalman filter reduces the carrier lock threshold by more than 7 dB compared to a 15-Hz constant-bandwidth loop. The Kalman filter-based strategy employs a soft-decision discriminator, explicitly models the effects of receiver clock noise, and optimally adapts the loop bandwidth to the carrier-to-noise ratio. In extensive simulation and in tests using actual wideband GPS data, the Kalman filter PLL demonstrates improved cycle slip immunity relative to constant bandwidth PLLs.Aerospace Engineering and Engineering Mechanic

    Real-time software receiver

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    A real-time software receiver that executes on a general purpose processor. The software receiver includes data acquisition and correlator modules that perform, in place of hardware correlation, baseband mixing and PRN code correlation using bit-wise parallelism

    ROMA (Rank-Ordered Multifractal Analysis) for intermittent fluctuations with global crossover behavior

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    Rank-Ordered Multifractal Analysis (ROMA), a recently developed technique that combines the ideas of parametric rank ordering and one parameter scaling of monofractals, has the capabilities of deciphering the multifractal characteristics of intermittent fluctuations. The method allows one to understand the multifractal properties through rank-ordered scaling or non-scaling parametric variables. The idea of the ROMA technique is applied to analyze the multifractal characteristics of the auroral zone electric field fluctuations observed by SIERRA. The observed fluctuations span across contiguous multiple regimes of scales with different multifractal characteristics. We extend the ROMA technique such that it can take into account the crossover behavior -- with the possibility of collapsing probability distributions functions (PDFs) -- over these contiguous regimes.Comment: 24 pages, 18 figure

    Modulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs cellular reprogramming

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    Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes deregulated by specific combinations of these EBNAs through unknown mechanisms. Comparing human genome binding by these viral transcription factors, we discovered that 25% of binding sites were shared by EBNA 2 and the EBNA 3s and were located predominantly in enhancers. Moreover, 80% of potential EBNA 3A, 3B or 3C target genes were also targeted by EBNA 2, implicating extensive interplay between EBNA 2 and 3 proteins in cellular reprogramming. Investigating shared enhancer sites neighbouring two new targets (WEE1 and CTBP2) we discovered that EBNA 3 proteins repress transcription by modulating enhancer-promoter loop formation to establish repressive chromatin hubs or prevent assembly of active hubs. Re-ChIP analysis revealed that EBNA 2 and 3 proteins do not bind simultaneously at shared sites but compete for binding thereby modulating enhancer-promoter interactions. At an EBNA 3-only intergenic enhancer site between ADAM28 and ADAMDEC1 EBNA 3C was also able to independently direct epigenetic repression of both genes through enhancer-promoter looping. Significantly, studying shared or unique EBNA 3 binding sites at WEE1, CTBP2, ITGAL (LFA-1 alpha chain), BCL2L11 (Bim) and the ADAMs, we also discovered that different sets of EBNA 3 proteins bind regulatory elements in a gene and cell-type specific manner. Binding profiles correlated with the effects of individual EBNA 3 proteins on the expression of these genes, providing a molecular basis for the targeting of different sets of cellular genes by the EBNA 3s. Our results therefore highlight the influence of the genomic and cellular context in determining the specificity of gene deregulation by EBV and provide a paradigm for host-cell reprogramming through modulation of enhancer-promoter interactions by viral transcription factors

    Electronic digital techniques

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